Deoxypodophyllotoxin inhibits the expression of intercellular adhesion molecule-1 induced by tumor necrosis factor-alpha in murine lung epithelial cells.

نویسندگان

  • Meihua Jin
  • Eunkyung Lee
  • Ju Hye Yang
  • Yue Lu
  • SangGu Kang
  • Young-Chae Chang
  • Seung Ho Lee
  • Seok-Jong Suh
  • Cheorl-Ho Kim
  • Hyeun Wook Chang
چکیده

Intercellular adhesion molecule-1 (ICAM-1) is associated with processes of inflammation. We investigated the effects of deoxypodophyllotoxin (DPT) on tumor necrosis factor-alpha (TNF-alpha) induced ICAM-1 expression in the mouse lung epithelial cell line, LA4. DPT (5 to 20 nM) inhibited TNF-alpha-induced ICAM-1 expression through nuclear factor-kappa B (NF-kappaB) in a dose-dependent manner and repressed ICAM-1 promoter activity. NF-kappaB reporter gene activity and DNA binding activity were also strongly inhibited. In addition, DPT inhibited degradation by the TNF-alpha induced inhibitory kappaB-alpha (IkappaB-alpha) in a concentration-dependent manner. Taken together with our previous results suggest DPT might provide a basis for novel anti-inflammatory drug development.

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عنوان ژورنال:
  • Biological & pharmaceutical bulletin

دوره 33 1  شماره 

صفحات  -

تاریخ انتشار 2010